Destroying the Box
From West Of Vipers Gate
The Box of Woe can be placed within itself. By adding or removing from the universe, or changing the size of the universe. This typically would mean a place where the universe is warped, such as one of the Elemental Clocks, the Sunken Wizard's Tower (harder now). But a magical item like the Golden Beehive which creates something from nothing could be used by having the box exist in the same place as the something created, probably destroying the item.
